Publications

Designer peptide-DNA cytoskeletons regulate the function of synthetic cells

Margaret L. Daly, Kengo Nishi, Stephen J. Klawa, Kameryn Y. Hinton, Yuan Gao & Ronit Freeman

Nature Chemistry, 2024

Uncovering supramolecular chirality codes for the design of tunable biomaterials

Stephen J. Klawa, Michelle Lee, Kyle D. Riker, Tengyue Jian, Qunzhao Wang, Yuan Gao, Margaret L. Daly, Shreeya Bhonge, W. Seth Childers, Toluope O. Omosun, Anil K. Mehta, David G. Lynn, Ronit Freeman

Nature Communications, 2024

From the lab to the field: Handheld surface enhanced Raman spectroscopy (SERS) detection of viral proteins

Taylor D Payne, Stephen J. Klawa, Tengyue Jian, Qunzhao Wang, Sang Hoon Kim, Ronit Freeman, and Zachary D. Schultz

Sensors and Diagnostics, 2023

SARS CoV-2 Evolved Variants Optimize Binding to Cellular Glycocalyx

S Kim, F L Kearns, M A Rosenfeld, L Votapka, L Casalino, M Papanikolas, R E Amaro, R Freeman

Cell Reports Physical Science, 2023

Bioactive Fibronectin-III10 DNA Origami Nanofibers Promote Cell Adhesion and Spreading

A Buchberger, K Riker, J Bernal-Chanchavac, RP Narayanan, CR Siammons, NE Fahmi, R Freeman, and N Stephanopoulos

ACS Appl. Bio Mater

Self-Assembling Biomaterials From Proteins, Peptides, and DNA

N Stephanopoulos, R Freeman, and H Yan

ACS Appl. Bio Mater

Mucus and Mucus Flake Composition and Abundance Reflect Inflammtory and Infection Status in Cystic Fibrosis

M R Markovetz, IC Garbarine, CB Morrison, WJ Kissner, I Seim, M. G Forest, M J. Papanikolas, R Freeman, A Ghio, N E Alexis, SM Stick, C Ehre, RC Bouncher, CR Esther, MS Muhlebach, DB Hill

Journal of cystic Fibrosis, 2022

Modeling Insights into SARS CoV-2 Respiratory Tract Infections Prior to Immune Protections

A Chen, T Wessler, K Daftari, K Hinton, RC Boucher, R Pickles, R Freeman, SK Lai, MG Forest

Biophysical Journal, 2022

Mucus Concentration-Dependent Biophysical Abnormalities Unify Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

T Kato, G Radicioni, MJ Papanikolas, GV Stoychev, MR Markovetz, K Aoki, M Porterfield, K Okuda, SM B Cardenas, RC Gilmore, CB Morrison, C Ehre, KA Burns, KK White, TA Brennan, HP Goodell, H Thacker, HT Loznev, LJ Forsberg, T Nagase, M Rubinstein, SH Randell, M Tiemeyer, DB Hill, M Kesimer, WK O’Neal, ST Ballard, R Freeman, B Button, RC Bouche

Science Advances, 2022

GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses

SH Kim, FL Kearns, MA Rosenfeld, L Casalino, MJ Papanikolas, C Simmerling, RE Amaro, and R Freeman

ACS Cent. Sci., 2022

Molecular Dynamics Simulations to Explore the Structure and Rheological Properties of Normal and Hyperconcentrated Airway Mucus

Andrew G. Ford, Xue-Zheng Cao, Micah J. Papanikolas, Takafumi Kato,Richard C. Boucher, Matthew R. Markovetz, David B. Hill, Ronit Freeman, Mark Gregory Forest

Studies in Applied Mathematics, 2021

Catching COVID: Engineering Peptide-Modified Surface-Enhanced Raman Spectroscopy Sensors for SARS-CoV-2

TD Payne, SJ Klawa, T Jian, SH Kim, MJ Papanikolas, R Freeman, ZD Schultz

ACS Sens, 2021

Hydrogen Bonding Stiffens Peptide Ampiphile Supramolecular Filaments by Aza-Glycine Residues

JM Godbe, R Freeman, JA Lewis, IR Sasselli, MH Sangji, SI Stupp

Acta Biomaterialia, 2021

A Programmable Toolkit to Dynamically Signal Cells Using Peptide Strand Displacement

K Riker, ML Daly, M Papanikolas, T Jian, SJ Klawa, JS Sahin, D Liu, A Singh, AG Miller,  R Freeman

ACS Applied Materials & Interfaces, 2021

New Functions Emerging From Peptide-DNA Materials

ML Daly, SJ Klawa, R Freeman

Peptide-Based Biomaterials, 2020

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

D Dems, R Freeman, KD Riker, T Coradin, SI Stupp*, C Aimé

Acta Biomaterialia, 2020

Transforming Growth Factor β-1 Binding by Peptide Amphiphile Hydrogels

JA Lewis, R Freeman, JK Carrow, TD Clemons, LC Palmer, SI Stupp*

ACS Biomater, 2020

Supramolecular Exchange among Assemblies of Opposite Charge Leads to Hierarchical Structures

JR Wester, JA Lewis, R Freeman, H Sai, LC Palmer, SE Henrich, SI Stupp*

J. Am. Chem. Soc., 2020

Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture

JM Godbe, R Freeman, LF Burbulla, J Lewis, D Krainc, SI Stupp

ACS Biomater. Sci. Eng, 2020

Hierarchical Assembly of DNA Origami Nanostructures Using Coiled-coil Peptides

A Buchberger, C Simmons, N Fahmi,R Freeman, N Stephanopoulos

J. Am. Chem. Soc., 2019

DNA-Peptide Amphiphile Nanofibers Enhance Aptamer Function

C Serrano, R Freeman, J Godbe, J Lewis, S Stupp

ACS Applied Bio Materials, 2019

DNA-based materials as self-assembling scaffolds for interfacing with cells

Nicholas Stephanopoulos, Ronit Freeman

Science Direct, 2018

Reversible self-assembly of superstructured networks

R Freeman, M Han, Z Álvarez, JA Lewis, JR Wester, N Stephanopoulos, …

Science, 2018

Instructing cells with programmable peptide DNA hybrids

R Freeman, N Stephanopoulos, Z Alvarez, JA Lewis, S Sur, CM Serrano, …

Nature Communications, 2017

Biopolymers and supramolecular polymers as biomaterials for biomedical applications

R Freeman, J Boekhoven, MB Dickerson, RR Naik, SI Stupp

MRS Bulletin, 2015

Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons

N Stephanopoulos, R Freeman, HA North, S Sur, SJ Jeong, F Tantakitti, …

Nano Letters, 2014

Optical Aptasensors for the Analysis of the Vascular Endothelial Growth Factor (VEGF)

Ronit Freeman, Julia Girsh, Amily Fang-Jou, Ja-an Annie Ho, Thoman Hug, Jens Dernedde, Itamar Willner

ACS Publications, 2012

Sensing and Biosensing with Semiconductor Quantum Dots

Ronit Freeman, Julia Girsh,Bilha Willner, Itamar Willner

IJC, 2012

Functionalized CdSe/ZnS QDs for the detection of nitroaromatic or RDX explosives

R Freeman, T Finder, L Bahshi, R Gill, I Willner

Advanced Materials, 2012

Optical aptasensors for the analysis of the vascular endothelial growth factor (VEGF)

R Freeman, J Girsh, A Fang-ju Jou, JA Ho, T Hug, J Dernedde, I Willner

Analytical Chemistry, 2012

DNAzyme‐Like Activity of Hemin–Telomeric G‐Quadruplexes for the Optical Analysis of Telomerase and its Inhibitors

R Freeman, E Sharon, C Teller, A Henning, Y Tzfati, I Willner

ChemBioChem, 2010

Optical, electrical and surface plasmon resonance methods for detecting telomerase activity

E Sharon, R Freeman, M Riskin, N Gil, Y Tzfati, I Willner

Analytical Chemistry, 2010

CdSe/ZnS quantum dots-G-quadruplex/hemin hybrids as optical DNA sensors and aptasensors

E Sharon, R Freeman, I Willner

Analytical Chemistry, 2010

Detection of Explosives Using Field‐Effect Transistors

E Sharon, R Freeman, I Willner

Electroanalysis: An International Journal, 2009

β-cyclodextrin-modified CdSe/ZnS quantum dots for sensing and chiroselective analysis

R Freeman, T Finder, LL Bahshi, I Willner

Nano Letters, 2009

Enzyme cascades activated on topologically programmed DNA scaffolds

OI Wilner, Y Weizmann, R Gill, O Lioubashevski, R Freeman, I Willner

Nature nanotechnology, 2009

Supramolecular cocaine− aptamer complexes activate biocatalytic cascades

R Freeman, E Sharon, R Tel-Vered, I Willner

Journal of the American Chemical Society, 2009

Biosensing and probing of intracellular metabolic pathways by NADH‐sensitive quantum dots

R Freeman, R Gill, I Shweky, M Kotler, U Banin, I Willner

Angewandte Chemie International Edition, 2009

Switchable motion of DNA on solid supports

J Elbaz, R Tel‐Vered, R Freeman, HB Yildiz, I Willner

Angewandte Chemie, 2009

Analysis of Dopamine and Tyrosinase Activity on Ion‐Sensitive Field‐Effect Transistor (ISFET) Devices

R Freeman, J Elbaz, R Gill, M Zayats, I Willner

Chemistry-A European Journal, 2007

Following a protein kinase activity using a field-effect transistor device

R Freeman, R Gill, I Willner

Chemical Communications, 2007

Self-assembly of semiconductor quantum-dots on electrodes for photoelectrochemical biosensing

R Freeman, R Gill, M Beissenhirtz, I Willner

Photochemical & Photobiological Sciences, 2007

Probing Biocatalytic Transformations with CdSe− ZnS QDs

R Gill, R Freeman, JP Xu, I Willner, S Winograd, I Shweky, U Banin

Journal of the American Chemical Society, 2006