A cell is a dynamic structure that interacts with its surroundings in a variety of ways. Researching and understanding these interactions, behaviors, and the mechanisms behind them make it possible to guide cells to have them do what we want them to. Knowing exactly what both these cells and their surrounding environments are made of, we can guide biological materials to naturally do what we want them to – as well as have them naturally interact with synthetic materials for even more robust interfaces and greater control.