Bioinspired Solutions for Mucus Airway Obstruction

Overview

The lungs are a delicate, yet, vital organ for which serious disease can be extremely dangerous. According the WHO, 3 of the top 10 leading causes of death are related to the lungs. Mucus is a natural substance produced by the body for lubrication, digestion, foreign object removal and other tasks. Too much mucus, however, can cause problems with breathing and obstruction of the airways – a feature of highly deadly diseases like COPD.  At the Freeman Lab, our goal is to develop the safest and most effective ways to reverse the effects of mucus airway obstruction. 

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We are currently open to new funders and research partners for our work with mucus airway obstruction

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Related Publications

Mucus and Mucus Flake Composition and Abundance Reflect Inflammtory and Infection Status in Cystic Fibrosis

M R Markovetz, IC Garbarine, CB Morrison, WJ Kissner, I Seim, M. G Forest, M J. Papanikolas, R Freeman, A Ghio, N E Alexis, SM Stick, C Ehre, RC Bouncher, CR Esther, MS Muhlebach, DB Hill

Journal of cystic Fibrosis, 2022

Modeling Insights into SARS CoV-2 Respiratory Tract Infections Prior to Immune Protections

A Chen, T Wessler, K Daftari, K Hinton, RC Boucher, R Pickles, R Freeman, SK Lai, MG Forest

Biophysical Journal, 2022

Mucus Concentration-Dependent Biophysical Abnormalities Unify Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

T Kato, G Radicioni, MJ Papanikolas, GV Stoychev, MR Markovetz, K Aoki, M Porterfield, K Okuda, SM B Cardenas, RC Gilmore, CB Morrison, C Ehre, KA Burns, KK White, TA Brennan, HP Goodell, H Thacker, HT Loznev, LJ Forsberg, T Nagase, M Rubinstein, SH Randell, M Tiemeyer, DB Hill, M Kesimer, WK O’Neal, ST Ballard, R Freeman, B Button, RC Bouche

Science Advances, 2022

Molecular Dynamics Simulations to Explore the Structure and Rheological Properties of Normal and Hyperconcentrated Airway Mucus

Andrew G. Ford, Xue-Zheng Cao, Micah J. Papanikolas, Takafumi Kato,Richard C. Boucher, Matthew R. Markovetz, David B. Hill, Ronit Freeman, Mark Gregory Forest

Studies in Applied Mathematics, 2021